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UNMC study shows probiotics prevent sepsis in infants

UNMC

A research team at the University of Nebraska Medical Center College of Public Health has determined that a special mixture of good bacteria in the body reduced the incidence of sepsis in infants in India by 40 percent at a cost of only $1 per infant, according to a press release by UNMC. The findings are reported in the Aug. 16 issue of the journal Nature (http://dx.doi.org/10.1038/nature23480).

Pinaki Panigrahi, M.D., Ph.D., professor, epidemiology and pediatrics, Center for Global Health and Development, and his colleagues in the College of Public Health, led the international research team. The results reflect a culmination of 15 years of research and could seriously impact infant health worldwide.

The special mixture included a probiotic called Lactobacillus plantarum ATCC-202195 combined with fructo-oligosaccharide (FOS), an oral synbiotic preparation developed by Panigrahi.

Probiotics are live bacteria and yeasts that are good for your health, especially your digestive system. Synbiotics are combinations of probiotics with an FOS supplement that promotes growth and sustains colonization of the probiotic strain. FOS, naturally found in breast milk and such plants as onion, chicory, garlic, asparagus, banana, artichoke and others, is food for the probiotic bacteria.

Sepsis is a severe complication of bacterial infection that results in around one million infant deaths worldwide each year, mostly in developing countries. It occurs when the immune system stops fighting germs and begins to turn on itself and can lead to tissue damage, organ failure and death.

It is estimated that 40 percent of patients with severe sepsis in developing countries do not survive. When children and adults are included, the inpatient cost for managing patients with sepsis in U.S. hospitals is nearly $24 billion each year.

“This is the largest clinical trial of probiotics in newborns funded by the National Institutes of Health,” Panigrahi said. The team enrolled more than 4,500 newborns from 149 villages in the Indian province of Odisha and followed them for their first 60 days, the most critical period when they get sick and die.

During their first days of life, the newborns were administered the oral preparation for seven days.

Results of the randomized, double-blind, placebo-controlled study showed that sepsis and deaths in the first two months of infancy were reduced by 40 percent, more than twice the anticipated reduction of 20 percent. The synbiotic treatment also lowered respiratory tract infections.

The effectiveness demonstrated in Dr. Panigrahi’s study was so successful the study was halted early.

The probiotic formula could be a “very cheap oral sepsis vaccine,” Panigrahi said.

The study’s team from UNMC included: Pinaki Panigrahi, M.D., Ph.D., professor and principal investigator; Lorena Baccaglini, D.D.S., Ph.D., associate professor, epidemiology; and Dinesh Chandel, Ph.D., research assistant professor, environmental, agricultural & occupational health, Center for Global Health and Development in the College of Public Health.

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